PureTested Standard

The PureTested Certification Standard provides a science-based framework for evaluating chemical contaminants in finished personal care products or individual ingredients used to formulate such products through independent analytical testing. Unlike ingredient-based claims, this Standard assesses what is actually present in the final consumer-ready product, including non-intentionally added substances that may arise from raw materials, manufacturing processes, packaging interactions, or degradation.


The Program is founded on the recognition that exposure to certain chemical contaminants may contribute to adverse health outcomes. By identifying and reducing the presence of such contaminants where detected, the Standard supports efforts to lower preventable chemical exposures and promote consumer well-being, as well as improvements in product and supply chain transparency. The Standard focuses on contaminants and associated human health hazards and does not evaluate environmental fate characteristics such as persistence or bioaccumulation.


Products are evaluated using NTA and a structured hazard determination framework. Certain high-severity hazards, such as recognized carcinogens, endocrine disruptors, and reproductive or developmental toxicants, are subject to zero tolerance. All other detected contaminants are assessed through a cumulative, weighted health hazard evaluation to determine a clear Pass or Fail outcome.

 

This certification does not constitute a determination of product safety or risk for individual users, nor does it replace regulatory compliance requirements. Rather, it provides a transparent, reproducible method for substantiating clean product claims based on finished-product contaminant testing.


Certification applies only to the specific product evaluated and reflects analytical findings at the time of testing.
 

Contents

1. Purpose and Intended Use

2. What This Certification Does and Does Not Claim

3. Analytical Approach and Rationale

4. Interpretation and Limitations of Analytical Results

5. Program Decision Level (DL)

6. Identification Confidence Levels

7. Inclusion Criteria for Contaminant Evaluation

8. Authoritative Hazard Determination Framework

9. Zero-Tolerance Health Hazard Categories

10. Cumulative Health Hazard Evaluation

11. Pass / Fail Determination

12. Sampling, Testing Frequency, and Quality System Requirements

13. Scope and Eligibility

14. Program Governance, Updates, and Revisions

15. Confidentiality and Data Handling

16. Fee Structure

Definitions

For purposes of this Standard, the following terms apply:


Clean Product
A finished product that does not contain disqualifying zero-tolerance contaminants and whose cumulative hazard score meets or exceeds the Program’s acceptable cumulative hazard threshold based on analytical evaluation conducted under this Standard.


Contaminant
A chemical constituent present in a finished product that is not intentionally listed on the product ingredient label and that meets the inclusion criteria defined in Section 7. Contaminants may include NIAS (see below), but are defined based on detection in the finished product rather than source.


Non-Intentionally Added Substance (NIAS)
A substance present in a product that is not deliberately added, but arises from sources such as raw material impurities, chemical reactions or degradation, manufacturing processes, packaging interactions, or environmental exposure.
 

Finished Product
A consumer-ready product in its final packaged form, intended for distribution or sale.
 

Raw Material
An individual ingredient, blend, or pre-formulated input supplied for use in the manufacture of a finished personal care product.
 

Program Decision Level (DL)
The defined concentration threshold (1 µg/g or 1 ppm), expressed on a mass basis) at or above which a detected substance is considered present for compliance determination under this Standard.
 

Identification Confidence Level
The tiered classification assigned to a detected chemical (Confirmed, Probable, or Tentative) based on the strength and quality of analytical evidence, as defined in Section 6.
 

Zero-Tolerance Health Hazard
A hazard classification category that results in automatic failure of certification when a qualifying substance is detected at or above the Program Decision Level, as defined in Section 9.
 

Cumulative Hazard Evaluation
The structured, weighted assessment of detected contaminants across multiple health hazard categories for the purpose of determining whether a finished product meets the Program’s clean product criteria.
 

Pass / Fail Designation
The final certification determination assigned to a finished product following evaluation under this Standard.
 

Nontargeted Analysis (NTA) and Suspect Screening
Suspect screening involves matching detected features to compounds from a predefined chemical list or library, whereas nontargeted analysis (NTA) aims to identify all detectable chemicals without relying on a predefined target list. In practice, suspect screening often evaluates both listed (target) compounds and additional, non-listed features. As a result, suspect screening and NTA are frequently grouped together under the broader term “NTA.” In these standards, such analysis is referred to as NTA.
 

1. Purpose and Intended Use

This Standard is designed to enable consumer companies and suppliers to demonstrate that a finished product meets defined clean product criteria based on independent contaminant testing, rather than solely on ingredient disclosure or formulation intent.
Ingredient lists describe substances intentionally added to a product but do not capture non-intentionally added substances, process-related impurities, degradation products, or contaminants introduced through manufacturing, packaging, or supply chains. As a result, ingredient-based claims alone are insufficient to characterize the full chemical profile of a finished product.
This certification provides a structured, science-based framework for evaluating chemical contaminants present in finished personal care products and/or their ingredients and determining whether the overall contaminant profile meets the Program’s clean product criteria.
The certification is intended for adoption by personal care suppliers, manufacturers, brand owners, and retailers seeking to substantiate clean product claims through analytical testing and cumulative hazard evaluation. It does not replace regulatory compliance, ingredient disclosure requirements, or product safety assessments.
Certification applies only to the specific finished product tested and does not constitute endorsement of a company, brand, formulation philosophy, or ingredient portfolio.

2. What This Certification Does and Does Not Claim

2.1 What This Certification Does Claim
This certification provides a standardized, science-based framework for evaluating chemical contaminants (arising from various sources listed below) present in finished personal care products using independent analytical testing.
Certification allows companies to demonstrate that a product meets clean product criteria based on what is present in the finished product, rather than solely on ingredient lists, supplier documentation, or marketing claims.
The certification evaluates contaminants arising from raw materials, manufacturing processes, packaging interactions, or other non-intentional sources. It includes the assessment of hazardous chemicals that are legally present as incidental contaminants. It incorporates both absolute exclusions for certain high-severity health hazards and a cumulative evaluation of health hazards across multiple categories.
Certification outcomes are determined through a transparent, reproducible Pass/Fail assessment intended to support substantiated clean product claims and internal quality assurance.

 

2.2 What This Certification Does Not Claim
Certification does not constitute a determination of product safety, toxicity, or risk for individual users or populations, nor does it replace regulatory safety assessments.
Certification does not imply that a product is free from all chemicals, free from all contaminants, or risk-free. It also does not imply that products not certified under this Standard are unsafe.
Certification reflects analytical findings at the time of testing and does not guarantee identical contaminant profiles in future production batches or lots unless re-evaluated.
This certification evaluates chemical contaminants present in finished products and associated human health hazard considerations. It does not evaluate environmental fate characteristics such as environmental persistence, bioaccumulation, or long-range environmental transport, which are outside the scope of this Standard.

3. Analytical Approach and Rationale

Independent investigations have demonstrated that personal care products and their ingredients may contain chemical constituents that are not disclosed on product labels or that are inconsistent with labeling claims. Such constituents may arise from raw materials, manufacturing processes, packaging interactions, or other sources of non-intentional contamination.
Targeted analytical methods are limited to predefined analytes and may fail to detect unexpected, emerging, or non-intentionally added substances. NTA methods provide broader evaluative capability by enabling detection and identification of a wide and evolving range of known and unknown chemical contaminants.
Accordingly, the Program employs a NTA gas chromatography–mass spectrometry (GCxGC/MS-TOFMS) approach for contaminant evaluation in finished products. This approach supports high-purity determinations by identifying suspect chemicals beyond those captured by conventional targeted testing panels.
NTA informs compliance determinations under this Standard and does not preclude the use of targeted analytical methods where appropriate or required.

4. Interpretation and Limitations of Analytical Results

Analytical methods used under this Standard are intended to support the identification of chemical contaminants and inform certification compliance determinations.
NTA methods are designed to detect and identify a broad range of chemical constituents but do not provide precise quantitative concentration data across all chemical classes and product matrices. As a result, analytical findings are evaluated using a defined Program Decision Level (DL) as a compliance threshold rather than exact concentration measurements.
The NTA GCxGC/MS approach employed under this Standard is optimized for the detection of volatile and semi-volatile organic compounds. It is not designed to comprehensively detect inorganic elements, particulate materials, non-volatile polymers, or certain highly polar, ionic, thermally unstable, or high-molecular-weight substances.
Accordingly, some chemical classes may not be fully characterized using this method alone, including elemental contaminants (e.g., heavy metals), nanomaterials, non-volatile chemicals, and select highly fluorinated or strongly water-soluble compounds. Where warranted by product type or risk profile, the Program may require additional analytical evaluation.
NTA relies on spectral libraries and chemical databases for compound identification. Accordingly, chemicals that have not been previously characterized, cataloged, or documented in reference databases may not be definitively identified through routine screening workflows. Structural elucidation of unknown compounds is resource-intensive and requires targeted follow-up investigation, which is beyond the scope of standard certification screening. As a result, the analytical program is designed to identify known and reasonably characterizable substances rather than to comprehensively resolve all unknown chemical features.
Furthermore, each analytical platform exhibits inherent detection biases based on compound volatility, ionization efficiency, thermal stability, and chromatographic behavior. While the GCxGC/MS approach provides broad coverage of volatile and semi-volatile organic compounds, certain chemical classes—including highly polar, strongly ionic, polymeric, or poorly ionizing substances—may require alternative analytical techniques for full characterization. The Standard therefore recognizes that NTA enhances transparency and contaminant detection but does not represent an exhaustive characterization of all possible chemical constituents.
Absence of detection above the Program Decision Level does not imply absence of a substance at lower concentrations, nor does it constitute a determination of product safety. Conversely, identification of a substance at or above the Decision Level indicates presence relevant for certification evaluation under this Standard.
Detected substances are interpreted in the context of both identification confidence and conservative concentration estimation. Chemicals are assigned identification confidence levels (Confirmed, Probable, or Tentative) based on the strength of analytical evidence, as described in Section 6. Concentrations derived from NTA are semi-quantitative and are intended to represent conservative lower-bound estimates, rather than absolute quantities.
Estimated concentrations are calculated using internal standard–based response ratios and do not explicitly account for compound-specific extraction efficiency or response factors. The internal standard employed for estimation is a high-performing compound documented under established semi-volatile analytical methods, resulting in concentration values that are likely underestimated. Accordingly, reported concentrations should be interpreted as minimum estimated levels relevant for compliance screening purposes.
All analytical results, including chemical identifications and estimated concentrations, undergo expert review prior to use in scoring and certification determinations.
Analytical results generated under this Standard are interpreted solely for certification compliance purposes and are not intended to serve as exposure assessments, quantitative risk characterizations, or product safety determinations, nor do they constitute a comprehensive chemical inventory of the product. Interpretation prioritizes consistency, reproducibility, and public health protection over maximum analytical sensitivity.

5. Program Decision Level (DL)

For the purposes of this Standard, a substance is considered detected when identified by the Program’s NTA GCxGC/MS method at or above the Program Decision Level.
 

The Program Decision Level (DL) is defined as:
1 µg/g (1 ppm) in the finished product, expressed on a mass basis.

 

Although analytical instrumentation may be capable of detecting substances below this level, NTA methods do not reliably support precise quantification across diverse chemical classes. The Program Decision Level represents a compliance determination threshold, not an analytical limit of detection or health-based benchmark.

6. Identification Confidence Levels

For the purposes of this Standard, detected chemicals are assigned an identification confidence level based on the strength and quality of analytical evidence. Confirmed (Level 1), Probable (Level 2), and Tentative (Level 3) designations are used to transparently communicate confidence in chemical identification and to support consistent interpretation of NTA results.

 

Confirmed (Level 1)
Chemicals with a chromatographic and mass spectrometric match to an authentic reference standard, including agreement in retention time and mass spectral fragmentation patterns.
 

Probable (Level 2)
Chemicals with a probable structure supported by diagnostic evidence, such as accurate mass measurements, isotope patterns, and high-quality spectral library matches consistent with the proposed compound.
 

Tentative (Level 3)
Tentative (level 3) is used for library matches with a probable chemical class identification but with uncertainty surrounding the exact structure with respect to features such as chain length, branching, and ring substitution pattern. In such cases, hazard classification is based on the assigned chemical identity and corresponding authoritative determinations, subject to expert review.

 

For substances falling within zero-tolerance health hazard categories, identification confidence level does not modify exclusion criteria. Following expert review, detection of such substances at or above the Program Decision Level results in automatic Fail, irrespective of identification tier.

7. Inclusion Criteria for Contaminant Evaluation

A chemical constituent is included in contaminant evaluation when all of the following conditions are met:

  • The substance is not intentionally listed on the product ingredient label
  • The substance is detected at or above 1 µg/g (1 ppm)
  • The substance has a Confirmed, Probable, or Tentative identification confidence level

Substances below the Decision Level or lacking sufficient identification confidence are excluded from compliance determinations.
Substances meeting these criteria are included for hazard classification and compliance evaluation under this Standard.

8. Authoritative Hazard Determination Framework

Hazard classification is based on authoritative chemical identification using CAS Registry Numbers and determinations from a structured set of recognized hazard databases spanning regulatory, scientific, and screening-level sources
A strength-of-evidence hierarchy is applied, prioritizing authoritative regulatory and scientific determinations over screening-level data, in vitro-only indicators, or Quantitative Structure Activity Relationship (QSAR) predictions.
Absence of classification does not imply safety and may trigger additional review under the Program.
Authoritative and screening sources used to inform hazard classifications under this framework are listed in Section 18.

9. Zero-Tolerance Health Hazard Categories

Certain hazards are incompatible with a clean product designation due to the severity and irreversibility of potential health impacts. Substances in these categories are subject to zero tolerance.

 

Zero-tolerance categories:

  • Products will automatically fail certification if testing detects chemicals classified as known or presumed human carcinogens, as defined by one or more of the following authoritative bodies:
    • The International Agency for Research on Cancer (IARC)
    • The U.S. National Toxicology Program (NTP)
    • The U.S. EPA Integrated Risk Information System (IRIS)
    • California Proposition 65 (carcinogens)
  • Products will automatically fail certification if testing detects chemicals identified as endocrine disruptors or reproductive or developmental toxicants by one or more of the following authoritative regulatory bodies:
    • The European Commission, including substances identified on the EU Endocrine Disruptor Lists
    • The European Chemicals Agency (ECHA) under the REACH Candidate List of Substances of Very High Concern (SVHC), including substances identified for endocrine-disrupting, reproductive, or developmental toxicity
    • California Proposition 65, including chemicals listed for reproductive toxicity or developmental toxicity

This determination is based on hazard classification, independent of detected concentration. Classification applies regardless of exposure route, formulation type, or source of contamination.
Detection of any zero-tolerance substance at or above the Program Decision Level results in automatic Fail, irrespective of cumulative hazard considerations or scores.

10. Cumulative Health Hazard Evaluation

In the absence of zero-tolerance hazards, detected contaminants are evaluated cumulatively across multiple human health hazard categories, including carcinogenicity, endocrine activity, reproductive and developmental toxicity, genotoxicity, neurotoxicity, organ system toxicity, immunotoxicity, respiratory toxicity, and irritation, as well as toxicity to wildlife (ecotoxicity) with potential impacts on human health.
Lower-certainty hazards (e.g., suspected carcinogenicity) are not automatic exclusions but contribute to the cumulative hazard evaluation. No single lower-severity hazard determines the outcome in isolation.
Hazard categories are weighted to reflect differences in severity, reversibility, and population vulnerability. Structured adjustments are applied to address missing data and prevent bias.
The results of the cumulative hazard evaluation are translated into a product-level score using the Program’s established scoring methodology. Products receiving a score of 80 or greater are considered to fall within the Program’s acceptable cumulative hazard threshold for a clean product designation. Scores below this threshold indicate that the contaminant profile exceeds acceptable limits under this Standard.

11. Pass / Fail Determination

A product receives a Pass designation when:

  • No zero-tolerance hazards are detected at or above the Decision Level, and
  • The cumulative hazard evaluation indicates the contaminant profile meets clean product criteria (80 or over, as defined by the Program’s cumulative hazard scoring methodology).

A product receives a Fail designation when:

  • One or more zero-tolerance hazards are detected at or above the Decision Level, or
  • The cumulative hazard evaluation results in a product score below the Program’s acceptable cumulative hazard threshold. Products with scores near the acceptable cumulative hazard threshold may undergo qualitative expert evaluation for pass/fail criteria, taking into account product use and estimated contaminant concentration, conducted with a precautionary approach that prioritizes consumer protection.

No numerical scores or tiers are communicated as part of the certification.

12. Sampling, Testing Frequency, and Quality System Requirements

12.1 Testing Frequency and Sampling Requirements
Certified products are subject to annual re-testing to verify continued compliance with this Standard.
A minimum of one finished-product sample in a given production lot is required for testing, in consumer packaging, unless otherwise specified by the Program.
Samples must represent routine commercial production and may be sourced through manufacturer submission or independent product acquisition, as determined by the Program.
Certification applies only to the specific product and lot(s) tested.


Additional testing may be required under the following circumstances:

  • Changes to product formulation
  • Changes to raw material suppliers
  • Changes to manufacturing location or process
  • Evidence of quality control failures or non-compliance

The Program reserves the right to request supplemental samples or adjusted testing frequency where product risk profile, manufacturing variability, analytical findings, or quality system considerations warrant further evaluation.
 

12.2 Raw Material, Manufacturer and Supplier Quality Documentation
In addition to finished-product testing, participating companies must demonstrate foundational quality and manufacturing control practices across their supply chain.
At a minimum, companies may be asked to provide documentations demonstrating that:

  • Raw material suppliers operate under recognized Good Manufacturing Practices (GMPs) or equivalent quality management systems appropriate to the material type.
  • Finished product manufacturing facilities follow applicable GMP standards for formulation, processing, packaging, and storage.
  • Supplier qualification and oversight processes are in place, including defined criteria for approval, performance monitoring, rejection, and corrective action.
  • Defined internal material specifications exist for raw materials and finished products.
  • Certificates of Analysis (COAs) or equivalent batch-level documentation are available to confirm conformity to established specifications.

Where feasible, manufacturers and/or suppliers may also be requested to provide documentation demonstrating contamination control practices, change management procedures, traceability systems, and batch-level recordkeeping to support supply chain transparency.
COAs and related batch documentation are considered supporting evidence of conformance to predefined specifications but do not independently verify absence of contaminants beyond those specifically tested. Accordingly, quality documentation is reviewed to support certification integrity but does not replace analytical testing conducted under this Standard.
 

12.3 Role of Quality Systems in Certification
Quality system documentation is used to:

  • Support interpretation of analytical findings
  • Identify potential sources of non-intentionally added substances
  • Inform decisions regarding additional testing or surveillance

Certification determinations are based on finished-product analytical results, with quality documentation serving as contextual support rather than a substitute for testing.

13. Scope and Eligibility

13.1 Products and Materials Covered
This Standard applies to:

  • Finished personal care products intended for topical, oral, or cosmetic use, and
  • Raw materials and ingredients used in the manufacture of personal care products, including substances supplied as individual ingredients, blends, or pre-formulated inputs.
     

13.2 Application of the Standard by Material Type
The application of this Standard differs by material type:

  • Finished products are evaluated through analytical testing and hazard evaluation to determine a Pass or Fail certification outcome.
  • Raw materials are evaluated through analytical testing to characterize non-intentionally added substances and potential hazard profiles for the purpose of ingredient qualification, supplier transparency, and risk management.
  • Raw material evaluation under this Standard does not, by itself, constitute certification of a finished product or imply suitability for all formulations or uses.

14. Program Governance, Updates, and Revisions

This Standard is maintained by the Program and is subject to periodic review and revision to reflect updates to analytical methods, authoritative hazard classifications, regulatory developments, and evolving scientific understanding.
Revisions to this Standard will be documented through version control and communicated to participating entities. Certification determinations are based on the version of the Standard in effect at the time analytical testing is conducted.
The Program may issue interpretive guidance or supplemental materials to support consistent application of this Standard. Such materials are informational in nature and do not supersede the requirements of this Standard unless explicitly stated.

15. Confidentiality and Data Handling

Analytical data, formulations, supplier information, and related materials provided under this Standard are subject to confidentiality protections governed by a mutually executed Non-Disclosure Agreement (NDA) between the Program and participating entities.
Information obtained through testing and evaluation is used solely for certification, quality assessment, and program administration purposes, except where disclosure is required by law or expressly authorized in writing by the participating entity.
Nothing in this Standard alters or supersedes the terms of any executed confidentiality or non-disclosure agreement.

16. Fees and Payment Terms

Participation in the Program is subject to applicable fees as established by the Program and published in the current Fee Schedule.
The Program applies a flat-rate fee per finished product submitted for evaluation. The fee structure may be adjusted at the Program’s discretion, including the provision of pilot or launch-partner pricing.
The Program may offer volume-based or multi-product pricing adjustments as described in the current Fee Schedule.
Payment of fees does not guarantee certification. Certification outcomes are determined solely by compliance with the requirements of this Standard.
The Program reserves the right to revise its Fee Schedule with reasonable notice to participating entities.

17. Scientific References

Hartnett, M. J.; Watson, W. D.; Janssen, J. A.; Hua, J.; Grossman, J.; Peng, Q.; Hartnett, P.; Favela, K. A. Rapid Screening of Consumer Products by GCxGC-HRT and Machine Learning Assisted Data Processing. J. Am. Soc. Mass Spectrom. 202334 (8), 1653–1662. https://doi.org/10.1021/jasms.3c00107. 

 

Vegosen, L.; Martin, T. M. An Automated Framework for Compiling and Integrating Chemical Hazard Data. Clean Technol. Environ. Policy 202022 (2), 441–458. 

 

Williams, A. J.; Lambert, J. C.; Thayer, K.; Dorne, J.-L. C. M. Sourcing Data on Chemical Properties and Hazard Data from the US-EPA CompTox Chemicals Dashboard: A Practical Guide for Human Risk Assessment. Environ. Int. 2021154, 106566. 

18. Authoritative and Screening Hazard Data Sources

Hazard classifications under this Standard are informed by a comprehensive set of authoritative regulatory sources and screening-level databases. These sources support hazard identification across multiple endpoints and reflect the integration of diverse toxicological and regulatory determinations. Inclusion in this list does not imply equal weighting across all sources; a strength-of-evidence hierarchy is applied as described in Section 8.

 

Authoritative Sources

Agency for Toxic Substances and Disease Registry (ATSDR). Neurological Substances Listing. Accessed April 20, 2026.

California Air Resources Board (CARB). Identified Toxic Air Contaminants List. Accessed April 20, 2026.

California Environmental Contaminant Biomonitoring Program (CECBP). Priority Chemicals List. Accessed April 20, 2026.

California Office of Environmental Health Hazard Assessment (OEHHA). Proposition 65 List. Accessed April 20, 2026.

California Office of Environmental Health Hazard Assessment (OEHHA). Reference Exposure Levels (RELs). Accessed April 20, 2026.

California State Water Resources Control Board. Drinking Water Notification Levels. Accessed April 20, 2026.

California State Water Resources Control Board. Maximum Contaminant Levels. Accessed April 20, 2026.

California State Water Resources Control Board. Water Body Pollutants List (303(d)). Accessed April 20, 2026.

European Chemicals Agency (ECHA). Classification, Labelling and Packaging (CLP) Inventory. Accessed April 20, 2026.

European Chemicals Agency (ECHA). REACH Candidate List of Substances of Very High Concern for Authorization. Accessed April 20, 2026.

European Commission. Annex VI: Carcinogens, Mutagens, and Reproductive Toxicants (CMRs). Accessed April 20, 2026.

European Commission. Annex VI: Respiratory Sensitizers. Accessed April 20, 2026.

European Commission. Endocrine Disruptor List. Accessed April 20, 2026.

European Commission. Persistent, Bioaccumulative, and Toxic Substances (PBTs). Accessed April 20, 2026.

European Commission. https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-products-specific-topics/fragrance-allergens-labelling_en. Accessed April 20, 2026.

German Research Foundation (DFG). MAK Commission. MAK and BAT Values. Accessed April 20, 2026.

Government of Canada. Persistent, Bioaccumulative, and Inherently Toxic (PBiT) Substances. Accessed April 20, 2026.

OSPAR Commission. Chemicals for Priority Action List. Accessed April 20, 2026.

US Department of Health and Human Services. National Toxicology Program (NTP). Office of Health Assessment and Translation: Reproductive and Developmental Toxicants. Accessed April 20, 2026.

US Department of Health and Human Services. National Toxicology Program (NTP). Report on Carcinogens. Accessed April 20, 2026.

US Environmental Protection Agency (EPA). Human Health Risk-Based Concentrations. Accessed April 20, 2026.

US Environmental Protection Agency (EPA). Integrated Risk Information System (IRIS). Accessed April 20, 2026.

US Environmental Protection Agency (EPA). National Waste Minimization Program Priority Chemicals. Accessed April 20, 2026.

US Environmental Protection Agency (EPA). Toxics Release Inventory (TRI). Accessed April 20, 2026.

National Institute for Occupational Safety and Health (NIOSH). List of Potential Occupational Carcinogens. Accessed April 20, 2026.

Washington State Department of Ecology. Persistent, Bioaccumulative Toxics (PBTs). Accessed April 20, 2026.

World Health Organization. International Agency for Research on Cancer (IARC). IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Accessed April 20, 2026.

 

Screening Sources

Commission des normes, de l’équité, de la santé et de la sécurité du travail (CNESST). Workplace Hazardous Materials Information System (WHMIS) Products Database. Accessed April 20, 2026.

ChemSec. Substitute It Now (SIN) List. Accessed April 20, 2026.

European Agency for Safety and Health at Work (EU-OSHA). Regulation (EC) No 1272/2008 (CLP). Accessed April 20, 2026.

Government of Canada. Domestic Substances List (DSL). Accessed April 20, 2026.

Government of Canada. Priority Substances Lists (2006). Accessed April 20, 2026.

Japan National Institute of Technology and Evaluation (NITE). GHS Classification Results. Accessed April 20, 2026.

Malaysia Department of Occupational Safety and Health. Industry Code of Practice on Chemicals Classification and Hazard Communication. Accessed April 20, 2026.

New Zealand Environmental Protection Authority. Chemical Classification and Information Database (CCID). Accessed April 20, 2026.

Safe Work Australia. Hazardous Chemical Information System (HCIS). Accessed April 20, 2026.

The Endocrine Disruption Exchange (TEDX). TEDX List of Potential Endocrine Disruptors. Accessed April 20, 2026.

University of Maryland (UMD). List of Acute Toxins, Teratogens, Carcinogens, or Mutagens (via ACToR). Accessed April 20, 2026.

US Environmental Protection Agency (EPA). Safer Chemical Ingredients List. Accessed April 20, 2026.

US Environmental Protection Agency (EPA). TSCA Work Plan for Chemical Assessments: 2014 Update. Accessed April 20, 2026.

US Environmental Protection Agency (EPA). Toxicity Estimation Software Tool (T.E.S.T.). Accessed April 20, 2026.

US Environmental Protection Agency (EPA). Toxicity Reference Database (ToxRefDB). Accessed April 20, 2026.

US Environmental Protection Agency (EPA). Toxicity Value Database (ToxValDB). Accessed April 20, 2026.

US National Library of Medicine. Hazardous Substances Data Bank (HSDB). Accessed April 20, 2026.